Re: 1969 inline 6 1250 merc
Agreed with Scaaty. You havta dump a fuel station into the engine before you can get it to start. What I normally do is to trim down the engine from it's trailer position, but not very far. Probably between 45 and 60 degree angle with the horizontal. Then I start priming till I get fuel from the carbs. Then trim it down further, full choke, and start. Reason I prime while the engine is at an angle is that I can't get fuel dripping from the carbs when the engine is near vertical. The needles and seats just seal too well.
So yes, don't worry about flooding the engine. Give it lots and lots of gas. Some guys squirt syringes with fuel/oil premix into each carb before they attempt a start up. Don't use commercial aerosol quick start cans though. They don't contain any lubricants.