Seen the inside of many an old motor and don't see why running 50:1 wouldn't be a problem with the newer more advanced 2 stroke oils on the market now. Lots of difference from the old oils of yester years.
My aftermarket service manual covering Merc 4 and 6 cylibder outboards1955-65.
It says Mix 12 ozs Formula 50 Quicksilver( assuming todays TCW3 rated oils meet these specs) outboard oil with each 5 gallons. Thats less than 50:1 2.4 ozs per gallon.
I would stick with 2.6 ozs per gallon.Again assuming the TCW3 oils meet the same standards.
You might go to johns old mercury web site and ask if todays TCW3 rated oils meet the same standards.
I can tell you My 65 Merc 500 has run on 50:1 all its life.