It may work. is it a short or long hub prop? is your outdrive set up for the long or short hub props? Long hub uses the cone with a center bolt to hold the prop, the short uses a flat washer with tabs that fold into the cone. fairly easy to determine.
secondly, is the 21 inch pitch too much for your boat? If its the bayliner in your signature, I would think its too much pitch. You need to be reaching 4800+ RPM at open throttle to avoid lugging the motor. good luck!