Re: 3.0 omc to 4.3 cobra
As stated above, the 4cyl cobras are not as sturdy as the v6/8 drives. changing from an inline engine to a v engine will require the fabrication of new engine mounts IF there is even room to do it. Cobras, also use ESA, so you would need to get all of those parts with your new engine, purchasing them aftermarket will get expensive. Rebuilding the drive = more work and money, and you still have a drive that is getting harder and harder to maintain. They are also VERY VERY sensitive to shift cable adjustment, get it wrong and you will be rebuilding it again.
All of this time effort and money - your really need to consider swapping in either a merc or vp. they all use the same cutout in the transom, except for the Gen2 alphas(they have two additional mounting holes - no big deal).