Re: 60 nissan runs rough until you run it at full throtle
What do the plugs look like? When was the last time the motor was de-carboned? Is the fuel fresh? Have you verified every bit of the fuel system, from the tank pickup to the carbs? Is the compression good?
A small pinhole leak in the fuel system might allow air into the system. If that is caused by a weak o-ring in a connector, it might seal up when the vacuum comes up while running at WOT. If there is some debris floating around in the carb bowls, that stuff can slosh around -- and sometimes cause problems, other times not.