With the drive installed the fittings that connect the drive to the reservoir bottle are open. Any pressure you blow into the drive will come out the bottle, not be contained (hopefully) within...
Those particular fittings CAN NOT be seal with the drive installed, they are in the bell housing itself. If you're so concerned about pulling the drive (and I don't see why!) then you could clamp off the hose between the transom housing and the reservoir bottle. But I wouldn't guarantee that method, besides, pulling the drive takes 6 minutes and just 2 tools. A screwdriver to release the clips on the end of the trim ram pin, and a 5/8" socket on a long extension to remove the 6 nuts holding the drive to the bell housing. Just remember to put it in forward gear before you start, and disconnect the speedo feed tube (at the top of the lower unit, in front of the shift shaft)....
Chris.......