My neighbor is a tile/marble guy. I helped him out 1 day when I was bored and he was working on a neighbors house.
His method was to figure out the tile spacing (12 3/8, 24 3/4, 37 1/8, etc), snap a center line, then go down the center line and snap lines at 24 3/4", then snap lines off the center line at 24 3/4. After the grid of 4 tile x 4 tile blocks (plus grout lines) was laid out he snapped 12 3/8 lines close to the walls so he could figure out all the cut tiles. After each line was snapped we hit it with clear sealer (rattle can of DEFT) to lock in the chalk line.
He said the grid pattern keeps the tiles square and if you get tile that is not 100% square or 100% the correct size the grid keeps the tile and grout lines accurate. If you rely on the tiles being accurate and use the plastic corner X's, the floor could get off,,, especially on a long run.
It took some time laying out the grid pattern and making sure everything was 100% square, but once that was done all the edge tile could be cut in 1 shot, no going back and forth to the tile saw while laying tile... Actually, as he was laying tile I was cutting the pre-marked edge pieces before he got to the section the cut tile needed to go,, or mixing thinset,,, I was the grunt for the day

We didn't use any of the plastic corner spacer X's and the tile came out prefect.
I lucked out helping him, gained a lot of knowledge for a few hours of grunt labor...