When we talk about low speed mixture we talk about the ratio air/fuel (gas mixed with oil) not the ratio of mixture gas/oil.
You will have the same issue in a 4 stroker, to lean mixture of air and fuel ....... hotter cumbustion.
Leaner mixture of air/fuel leads to hotter cumbustion in the cylinder and if to lean it will create detonation and at the end the piston will be hurt (start to melt). More fuel in the mixture relative to air will cool the cumbustion.
If you have lean conditions you either retard the timing or rich the mixture or both.If not you will ruin the piston/cylinder.
I do not know for sure about these Walboro or Tillotson which are at Chrysler/Force engines if the low speed circuit also is active at higher speed and WOT.
But I believe it, because from the sticky topic from Frank Acampora who was the guy who had most experience from these engines at this forum and he highly recommend not to set the low speed needle less then 3/4 turn out from seated,
What I know is that to lean conditions in the cumbustion camber leads to hotter cumbustion and the temperature will rise dramatically.